Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰、环碳酸酯、氧、脱碳酸酯、酰、环氨酸酯和环等成目标物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰和去乙酰由一对功能相互拮抗的蛋白酶——组蛋白乙酰转移酶和组蛋白去乙酰酶负责。